ivomec

[48180 Hunter]

Just wondering the exact way too give this? I was told 1 cc squirt into mouth.

[Done Gone Beagles]

hope I didn't kill anybody dog sorry said it wrong

[bpeterson]

I've been giving 0.1 CC. One tenth of a cc per 10 lbs of body weight.

[MaineDogs]

One cc per ten #s of your dog weight

This much can way over dose a beagle and kill it


1/10th of a CC per 10lbs of dog by mouth once a month, call and check with a vet if you feel you need to dose your hound with 1cc

[johns03272008]

1/10th a cc per 10lbs most beagles should be between 2-3/10ths a of cc

[billy]

it depends on the solution. The cattle solution (1%) is 1/10 cc per 10 pounds.

[johns03272008]

The 1% cattle/swine regular is what your wanting and squirted into their mouth

[Mo. Beagler 5000]

if you have a 25 lb dog and you always give it 2.5 cc's your SERIOUSLY overdosing your dog..

In dogs, symptoms of acute toxicity rarely occur at single dosages of 2 mg/kg (2000 mi­crograms/kg) or less. At 2.5 mg/kg mydriasis occurs, and at 5 mg/kg tremors occur. At doses of 10 mg/kg, severe tremors and ataxia are seen. Deaths occurred when dosages exceeded 40 mg/kg, but the LD50 is 80 mg/kg. Dogs (Beagles) receiving 0.5 mg/kg PO for 14 weeks developed no signs of toxicity, but at 1 - 2 mg/kg for the same time period, developed mydriasis and had some weight decreases. Half of the dogs receiving 2 mg/kg/day for 14 weeks developed symptoms of depression, tremors, ataxia, anorexia, and dehydration

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http://www.elephantcare.org/Drugs/ivermect.htm

I'm all for using cheaper meds but make sure you know how to do it. I am assuming the above post by Done Gone is a typo. Almost every place you can get ivomec is a 1 percent solution.

DO NOT GIVE YOUR DOG 1cc per 10 you will damage organs.. 1 cc is given if your dog already have heartworms and the risk of death from worms outweighs the risk of the drug toxicity. Also your just wasting about 20 doses!

[bigdogpace]

had female with mange my vet told me 1 cc everyday for 2 months and mayb some more it cured her completely dont think u can overdose a dog unless u got heart worms

[MPankratz]

I don't believe organ damage is likely in case of overdose. The drug is a positive allosteric modulator binding to a novel site on the GABA-A receptor complex, and it's primary toxicity results from this. Side effects listed are ataxia, sedation, tremors, etc. The dog basically becomes drunk (this is the same receptor ethanol binds to), and Ivermectin is actually being trialed as an anti-alcoholism drug. Mydriasis occurs first, but we can probably ignore that. Lots of drugs dilate the pupil and no ill effects result.

If I read correctly, Ivomec is 10mg/mL. If you're giving your 20 or 30lb dog a 20 or 30mg dose, you're definitely overdosing. However, for a 30lb dog, a 30mg dose is approximately 2.2mg/kg.

So, you're well below the LD50, and the level where acute toxicity would present. However, you are at the level where there's a 50% chance of sedation, ataxia, tremors, etc during chronic daily use. It would seem that this would quickly resolve itself with a modified dosing regimen.

I don't think you're at risk of killing your dog with a 1mL/10lb dose, but unless there's a specific reason you need a higher dose, you might as well save yourself some money and make it last.

I don't know why or how long you've been giving a dose this high, but if it's been long term, I'd be careful of sudden alteration in doses. With GABAergic drugs sudden withdrawal or dose reduction is well known to cause seizures and an incredibly painful withdrawal. Before I carefully discontinued the phenobarbital from my older dog missing a dose would make her extremely uncomfortable (phenobarbital has similar, but far more pronounced actions on the GABA-A receptor).